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Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling

Developmental Biology

Jul 19, 2008

Helen A ThomasonJill Dixon

Abstract

During embryogenesis, the transcription factor Tp63 is expressed in the basal cells of multiple epithelial tissues. In humans, mutations in TP63 have been identified in five distinct human developmental disorders that are characterized by limb abnormalities, ectodermal dysplasia, and fa...read more

Mentioned in this Paper

Embryo
Infantile Scurvy
Hedgehog Proteins
Pathogenic Aspects
Entire Oral Cavity
Biochemical Pathway
PAX9 gene
Mandible
Structure of Maxillary Process of Embryo
Abnormal Degeneration
Paper Details
References
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  • Citations42
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  • References43
  • Citations42
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Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling

Developmental Biology

Jul 19, 2008

Helen A ThomasonJill Dixon

PMID: 18634775

DOI: 10.1016/j.ydbio.2008.06.030

Abstract

During embryogenesis, the transcription factor Tp63 is expressed in the basal cells of multiple epithelial tissues. In humans, mutations in TP63 have been identified in five distinct human developmental disorders that are characterized by limb abnormalities, ectodermal dysplasia, and fa...read more

Mentioned in this Paper

Embryo
Infantile Scurvy
Hedgehog Proteins
Pathogenic Aspects
Entire Oral Cavity
Biochemical Pathway
PAX9 gene
Mandible
Structure of Maxillary Process of Embryo
Abnormal Degeneration

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Ciliary Signaling & Growth

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Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

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Paper Details
References
  • References43
  • Citations42
12345
  • References43
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12345
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