Facial Onset Sensory and Motor Neuronopathy: Further Evidence for a TDP-43 Proteinopathy

Case Reports in Neurology
Besa ZisoAnu Jacob

Abstract

Three patients with the clinical and investigation features of facial onset sensory and motor neuronopathy (FOSMN) syndrome are presented, one of whom came to a post-mortem examination. This showed TDP-43-positive inclusions in the bulbar and spinal motor neurones as well as in the trigeminal nerve nuclei, consistent with a neurodegenerative pathogenesis. These data support the idea that at least some FOSMN cases fall within the spectrum of the TDP-43 proteinopathies, and represent a focal form of this pathology.

Citations

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Mar 21, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Juan Francisco Vázquez-CostaTeresa Sevilla
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BETA
biopsy

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