Facile and Green Synthesis of Multicolor Fluorescence Carbon Dots from Curcumin: In Vitro and in Vivo Bioimaging and Other Applications

ACS Omega
Tathagata PalGopinath Packirisamy

Abstract

Early detection is the critical phase in the prognostic strategy of various life-threatening maladies like infectious diseases and cancer. The mortality rate caused by these diseases could be considerably reduced if they were diagnosed in the early stages of disease development. Carbon dots (C-dots), a relatively new and promising candidate in the fluorescent nanomaterial category, possess a perceptible impact on various bioapplications. Herein, we report a one-step facile hydrothermal synthesis that yields a novel surface-passivated carbon dot (CDP) from curcumin (as a green substrate) displaying high aqueous solubility. The physico-chemical characterization of thus synthesized C-dots was accomplished by an UV-visible spectrophotometer, fluorescence spectrophotometer, zetasizer, TEM, and FE-SEM to understand the formation of carbon dots with a 4-5 nm size near spherical nanoparticle with high colloidal stability. E. coli DH5α was engaged as the Gram-negative test organism and S. aureus as the Gram-positive in the biolabeling of bacteria. Cancer cell lines including colon cancer (HCT-15), lung cancer (A549), and mouse fibroblast (NIH 3T3) were evaluated and resulted in good biolabeling potential and less cytotoxicity. Zebrafish...Continue Reading

References

Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Sep 22, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Hengchao ZhangShuit-Tong Lee
Aug 3, 2013·Analytical Chemistry·Ruixue WangGuonan Chen
Oct 16, 2014·Chemical Society Reviews·Shi Ying LimZhiqiang Gao
Feb 24, 2015·Analytica Chimica Acta·Xiaojuan GongMartin M F Choi
Jul 3, 2015·Scientific Reports·Yan-Fei KangXue-Bo Yin
Jan 28, 2016·PloS One·Angom Ramcharan SinghSridhar Sivasubbu
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bodhisatwa DasSantanu Dhara
May 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meiying LiuYen Wei
Aug 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiyao TengHong Bi
Jun 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanxu YangBoon M Teo
Jul 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bharat BhushanP Gopinath

❮ Previous
Next ❯

Citations

Oct 9, 2019·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Priyanka R IpteAshis K Satpati
Dec 17, 2019·Current Pharmaceutical Design·Anisha AnandChih-Ching Huang
Jun 11, 2020·Journal of Cellular Physiology·Milad AshrafizadehSaeed Samarghandian
Feb 20, 2019·Molecular Biology Reports·Furkan AyazRükan Genç
May 28, 2019·RSC Advances·Kokkarachedu VaraprasadChandrasekaran Karthikeyan
Feb 24, 2020·Journal of Fluorescence·Gaurav Gopal NaikAlakh N Sahu
Dec 25, 2019·Inflammation·Furkan AyazRukan Genc
Dec 4, 2020·Nanoscale Research Letters·Linlin WangSeung Hyun Hur
Mar 5, 2021·Nanomedicine·Gaurav Gopal NaikAlakh N Sahu
Oct 28, 2019·ACS Applied Materials & Interfaces·Maha AlafeefDipanjan Pan
Mar 7, 2020·The Journal of Physical Chemistry. B·Jeison Manuel ArroyaveMaría Eugenia Centurión
Dec 11, 2020·ACS Sensors·Tina NaghdiHamed Golmohammadi
Jan 22, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiajia WuZhili Peng

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
dynamic light-scattering
X-ray
Fluorescence

Software Mentioned

ImageJ
UV
imageJ2
– VIS Analyst

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.