Facile development of biodegradable polymer-based nanotheranostics: Hydrophobic photosensitizers delivery, fluorescence imaging and photodynamic therapy

Journal of Photochemistry and Photobiology. B, Biology
Neeraj S ThakurUttam C Banerjee

Abstract

Photodynamic therapy (PDT) is reported to be a promising technique to eradicate various cancers. As most of the photosensitizers (PSs) are hydrophobic in nature, thus, the effective delivery of PSs at the targeted site is the main hurdle associated with PDT. Zinc phthalocyanine and Zinc naphthalocyanine are reported as good PSs, however, highly hydrophobic characteristics restrict their use for clinical applications. To circumvent this limitation here we developed the advanced polymer-based nano-delivery system having polyethylene glycol (PEG) coated polymeric core with ~90% PS encapsulation. The PEG coating was responsible for the stabilization of probe in the physiological environment and storage conditions. The developed theranostic probes showed efficient in vitro fluorescence and singlet oxygen quantum yields upon irradiation with 620-750 nm (30 mW/cm2) light. The clathrin-mediated endocytosis (CME) based mechanism of cellular internalization was evaluated. The fluorescence of treated MCF-7 cells showed the ability of the probes as imaging agents. Moreover, up to 65% cell inhibition showed their cytotoxic efficiency. Further, comparatively higher tumor-accumulation of PSs without significant hepato/nephro-toxicity shown in...Continue Reading

Citations

Apr 23, 2020·Pharmaceutics·Darío Manzanares, Valentín Ceña
Jul 3, 2020·Frontiers in Bioengineering and Biotechnology·Gopal PatelGuoyin Kai
Dec 31, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Gopal PatelUttam Chand Banerjee
Feb 7, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Neeraj S ThakurUttam C Banerjee
May 29, 2021·Journal of Photochemistry and Photobiology. B, Biology·Seema KirarUttam C Banerjee

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