Facile fabrication of luminescent hyaluronic acid with aggregation-induced emission through formation of dynamic bonds and their theranostic applications

Materials Science & Engineering. C, Materials for Biological Applications
Hongye HuangYen Wei

Abstract

Aggregation-induced emission (AIE) is an abnormal phenomenon, which has been extensively explored for various applications. Taken advantage of the unique AIE feature, a number of luminescent nanoprobes with strong fluorescence intensity could thus be fabricated through different strategies; however, the fabrication of AIE-active carbohydrate polymers is still challenge owing to the poor solubility of carbohydrate polymers in most of organic solvents. In this work, a rather facile strategy has been developed for fabricating AIE-active sodium hyaluronate (Sh) through the formation of dynamic phenyl borate between the phenylboronic acid groups of AIE dye (An-B(OH)2)) and Sh in a "one-pot" route. This reaction could occur under low temperature, air atmosphere and in the present water. The physicochemical properties, biocompatibility, biological imaging and drug delivery performance of the final An-Sh fluorescent organic nanoparticles (FNPs) were confirmed by different characterization techniques. Results suggested that An-Sh FNPs possess high water dispersibility, strong fluorescence, and good biocompatibility. These excellent properties make An-Sh FNPs great potential for biological imaging and controlled drug delivery application...Continue Reading

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Citations

Feb 19, 2020·Journal of Molecular Recognition : JMR·Paria Pashazadeh-PanahiReza Eivazzadeh-Keihan
Jun 26, 2020·Macromolecular Rapid Communications·Fatma AbdiRachel Auzély-Velty
Aug 10, 2019·Nanoscale Research Letters·Muhammad Khuram ShahzadAbdulaziz Alhazaa
Apr 21, 2019·International Journal of Biological Macromolecules·Ayub KarimzadehNasrin Shadjou
Aug 11, 2019·International Journal of Biological Macromolecules·Ahmad MobedAhad Mokhtarzadeh

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