Facile fabrication of microfluidic surface-enhanced Raman scattering devices via lift-up lithography

Royal Society Open Science
Yuanzi WuHongwei Ma

Abstract

We describe a facile and low-cost approach for a flexibly integrated surface-enhanced Raman scattering (SERS) substrate in microfluidic chips. Briefly, a SERS substrate was fabricated by the electrostatic assembling of gold nanoparticles, and shaped into designed patterns by subsequent lift-up soft lithography. The SERS micro-pattern could be further integrated within microfluidic channels conveniently. The resulting microfluidic SERS chip allowed ultrasensitive in situ SERS monitoring from the transparent glass window. With its advantages in simplicity, functionality and cost-effectiveness, this method could be readily expanded into optical microfluidic fabrication for biochemical applications.

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Citations

Jan 8, 2021·Comprehensive Reviews in Food Science and Food Safety·Wenlei ZhaiMeng Wang
Feb 26, 2021·Journal of Separation Science·Ling Xia, Gongke Li
Aug 3, 2021·ACS Materials Letters·Naihao ChiangPaul S Weiss
Oct 3, 2018·ACS Applied Materials & Interfaces·Marlitt ViehrigAnja Boisen

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Methods Mentioned

BETA
surface-enhanced Raman scattering
Raman scattering
chip
chips

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