Facile fabrication of microsphere-polymer brush hierarchically three-dimensional (3D) substrates for immunoassays

Chemical Communications : Chem Comm
Jiao MaJinghua Yin

Abstract

We propose a facile UV strategy to construct a hierarchically three-dimensional (3D) substrate that comprises a polystyrene (PS) microsphere layer on the cycloolefin polymer (COP) substrate and densely packed hydrophilic polymer brushes grafting from this 3D backbone. This hierarchical substrate gives a high antibody loading capacity and 3D manner of analyte capture, therefore enhancing detection signal while reducing background noise.

References

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Dec 5, 2013·ACS Applied Materials & Interfaces·Lingjie SongJinghua Yin
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May 20, 2014·Chemical Communications : Chem Comm·Peng XiaoTao Chen

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Citations

Feb 24, 2016·Journal of Inorganic Biochemistry·Puja ModyMatthew R Hartings
Jun 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiao MaJinghua Yin
Mar 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunyu ZhaoQiang Shi
Oct 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lingjie SongJinghua Yin

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