Facile fabrication of poly(L-lactic acid) microsphere-incorporated calcium alginate/hydroxyapatite porous scaffolds based on Pickering emulsion templates

Colloids and Surfaces. B, Biointerfaces
Yang HuChaoyang Wang

Abstract

In this study, we develop a facile one-pot approach to the fabrication of poly(L-lactic acid) (PLLA) microsphere-incorporated calcium alginate (ALG-Ca)/hydroxyapatite (HAp) porous scaffolds based on HAp nanoparticle-stabilized oil-in-water Pickering emulsion templates, which contain alginate in the aqueous phase and PLLA in the oil phase. The emulsion aqueous phase is solidified by in situ gelation of alginate with Ca(2+) released from HAp by decreasing pH with slow hydrolysis of D-gluconic acid δ-lactone (GDL) to produce emulsion droplet-incorporated gels, followed by freeze-drying to form porous scaffolds containing microspheres. The pore structure of porous scaffolds can be adjusted by varying the HAp or GDL concentration. The compressive tests show that the increase of HAp or GDL concentration is beneficial to improve the compressive property of porous scaffolds, while the excessive HAp can lead to the decrease in compressive property. Moreover, the swelling behavior studies display that the swelling ratios of porous scaffolds reduce with increasing HAp or GDL concentration. Furthermore, hydrophobic drug ibuprofen (IBU) and hydrophilic drug bovine serum albumin (BSA) are loaded into the microspheres and scaffold matrix, res...Continue Reading

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Citations

Jul 12, 2016·Journal of Biomaterials Science. Polymer Edition·Guiyong XiaoYupeng Lu
Aug 5, 2017·Materials·Guangzhao Zhang, Chaoyang Wang
Sep 23, 2018·Journal of Biomedical Materials Research. Part a·Jiali ShenMingqing Chen
Jul 25, 2019·AAPS PharmSciTech·Nermeen A Elkasabgy, Azza A Mahmoud
Sep 10, 2020·Frontiers in Bioengineering and Biotechnology·Betül Aldemir Dikici, Frederik Claeyssens
Feb 25, 2021·Macromolecular Bioscience·Fei LiuZhuohong Yang
Aug 19, 2021·Journal of Materials Science. Materials in Medicine·Jie XieYihe Hu

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