Facile Formation of Gold-Nanoparticle-Loaded γ-Polyglutamic Acid Nanogels for Tumor Computed Tomography Imaging

Bioconjugate Chemistry
Jianzhi ZhuXiangyang Shi

Abstract

The formation of gold nanoparticle (Au NP)-loaded γ-polyglutamic acid (γ-PGA) nanogels (NGs) for computed tomography (CT) imaging of tumors is reported. γ-PGA with carboxyl groups activated by 1-ethyl-3-[3-(dimethylamino)propyl] carbodiimide hydrochloride is first emulsified to form NGs and then in situ chemically cross-linked with polyethylenimine (PEI)-entrapped Au NPs with partial polyethylene glycol (PEG) modification ([(Au0)200-PEI·NH2-mPEG]). The formed γ-PGA-[(Au0)200-PEI·NH2-mPEG] NGs with a size of 108.6 ± 19.1 nm display an X-ray attenuation property better than commercial iodinated small-molecular-contrast agents and can be uptaken by cancer cells more significantly than γ-PGA-stabilized single Au NPs at the same Au concentrations. These properties render the formed NGs with an ability to be used as an effective contrast agent for the CT imaging of cancer cells in vitro and a tumor model in vivo. The developed hybrid NGs may be promising for the CT imaging or theranostics of different biosystems.

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Citations

Jan 4, 2019·Nanoscale·Xiangjun HanKhashayar Farsad
Feb 21, 2019·Microscopy Research and Technique·Mümin Mehmet KoçAsa H Barber
Jun 10, 2020·Nanomedicine·Changchang Zhang, Xiangyang Shi
Sep 19, 2019·Macromolecular Bioscience·Yu ZouXiangyang Shi
Jul 4, 2018·Contrast Media & Molecular Imaging·Min Wu, Jian Shu
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Xin YuanXiangyang Shi
Aug 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenjie SunXiangyang Shi
Nov 27, 2021·Advanced Healthcare Materials·Yonca KittelLaura De Laporte

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