Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug delivery

RSC Advances
Edyta NiezabitowskaTom O McDonald

Abstract

The geometries and surface properties of nanocarriers greatly influence the interaction between nanomaterials and living cells. In this work we combine multiwalled carbon nanotubes (CNTs) with poly-ε-caprolactone (PCL) to produce non-spherical nanocomposites with high aspect ratios by using a facile emulsion solvent evaporation method. Particles were characterised by dynamic light scattering (DLS), scanning electron microscopy (SEM), atomic force microscopy (AFM) and asymmetric flow field flow fractionation (AF4). Different sizes and morphologies of nanoparticles were produced depending on the concentration of the sodium dodecyl sulphate (SDS), CNTs and PCL. Rod-like PCL-CNT nanostructures with low polydispersity were obtained with 1.5 mg mL-1 of SDS, 0.9 mg mL-1 of CNTs and 10 mg mL-1 PCL. AFM analysis revealed that the PCL and PCL-CNT nanocomposite had comparatively similar moduli of 770 and 560 MPa respectively, indicating that all the CNTs have been coated with at least 2 nm of PCL. Thermogravimetric analysis of the PCL-CNT nanocomposite indicated that they contained 9.6% CNTs by mass. The asymmetric flow field flow fractionation of the samples revealed that the PCL-CNT had larger hydrodynamic diameters than PCL alone. Fina...Continue Reading

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Citations

Nov 19, 2019·Drug Delivery·Ketevan PaliashviliRichard M Day
Jan 16, 2020·Topics in Current Chemistry·Viviana NegriPilar López-Larrubia
Jan 6, 2021·Journal of Applied Toxicology : JAT·Nhuan Thi DoSe-Hwa Kim
Apr 20, 2021·ACS Omega·Nathan Zavanelli, Woon-Hong Yeo
Mar 27, 2021·Annual Review of Analytical Chemistry·Christine L PlavchakS Kim Ratanathanawongs Williams
Sep 15, 2021·Journal of Separation Science·Gaëtane Lespes, Valentin De Carsalade Du Pont

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Methods Mentioned

BETA
dynamic light scattering
scanning electron microscopy
AFM
flow fractionation

Software Mentioned

Malvern Zetasizer
PURELAB

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