PMID: 702292Oct 1, 1978

Facile separation of sulfonamides from their degradates by liquid--liquid extraction

Journal of Pharmaceutical Sciences
D W FinkJ Blodinger

Abstract

Regulation of acidity for protonation of the free N4-amine can provide for the selective liquid--liquid extraction isolation of a sulfonamide from its degradation products. This principle is applied for the stability-indicating determination of sulfacetamide in the presence of sulfanilamide, sulfaquinoxaline in feed, and sulfabromomethazine in dosage forms. In solution, sulfabromomethazine can exhibit photodecomposition to sulfamethazine. The mean relative errors of the these methods and the precision, represented by relative standard deviations, are each typically less than 2%.

References

Aug 4, 1976·Journal of Chromatography·P H Cobb, G T Hill
Jul 21, 1976·Journal of Chromatography·N NoseA Watanabe
Oct 29, 1975·Journal of Chromatography·W J Vandenheuvel, V F Gruber
May 1, 1973·Journal of Pharmaceutical Sciences·R B Poet, H H Pu
Jan 1, 1974·Journal of Medicinal Chemistry·G L BiagiM E Fracasso
Feb 1, 1972·Journal of Pharmaceutical Sciences·T C Kram
Feb 1, 1972·Journal of Pharmaceutical Sciences·M I Walash, S P Agarwal
Mar 1, 1971·Journal of Pharmaceutical Sciences·H R Klein, W J Mader
Jan 1, 1968·Journal of Pharmaceutical Sciences·J W Turczan
Dec 1, 1965·Journal of Chromatography·Y T LinT I Yang

Citations

Jan 18, 1989·Biochimica Et Biophysica Acta·V Bennett

Related Concepts

Animal Feed (Substance)
Drug Stability
Photodegradation
Acetopt
Sulfamethazine
Sulfanilamides
Sulfanilic Acids
Sulfaquinoxaline
Sulfonamides

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