Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles

ACS Applied Materials & Interfaces
Wei ChenJeffrey I Zink

Abstract

The use of nanocarriers to deliver poorly soluble drugs to the sites of diseases is an attractive and general method, and mesoporous silica nanoparticles (MSNs) are increasingly being used as carriers. However, both loading a large amount of drugs into the pores and still being able to release the drug is a challenge. In this paper, we demonstrate a general strategy based on a companion molecule that chaperones the drug into the pores and also aids it in escaping. A common related strategy is to use a miscible co-solvent dimethyl sulfoxide (DMSO), but although loading may be efficient in DMSO, this co-solvent frequently diffuses into an aqueous environment, leaving the drug behind. We demonstrate the method by using acetophenone (AP), an FDA-approved food additive as the chaperone for clofazimine (CFZ), a water-insoluble antibiotic used to treat leprosy and multidrug-resistant tuberculosis. AP enables a high amount of CFZ cargo into the MSNs and also carries CFZ cargo out from the MSNs effectively when they are in an aqueous biorelevant environment. The amount of loading and the CFZ release efficiency from MSNs were optimized; 4.5 times more CFZ was loaded in MSNs with AP than that with DMSO and 2300 times more CFZ was released...Continue Reading

References

Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Moo HuhKinam Park
Jul 8, 2010·Journal of Pharmaceutical Sciences·Ji Young KimRodolfo Pinal
Aug 5, 2010·Journal of the American Chemical Society·Courtney R ThomasJeffrey I Zink
Oct 25, 2011·The Journal of Antimicrobial Chemotherapy·Moloko C CholoRonald Anderson
Jan 5, 2012·Chemical Society Reviews·Zongxi LiJeffrey I Zink
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen
Jan 8, 2013·Journal of the American Chemical Society·Yi-Ping ChenChung-Yuan Mou
Feb 8, 2013·Accounts of Chemical Research·Derrick TarnC Jeffrey Brinker
Feb 14, 2013·Chemical Society Reviews·Si-Han WuHong-Ping Lin
Sep 17, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heebeom KooKwangmeyung Kim
Nov 6, 2013·Physical Chemistry Chemical Physics : PCCP·Seishi ShimizuSteven Abbott
Aug 22, 2014·The Journal of Physical Chemistry. B·Seishi Shimizu, Nobuyuki Matubayasi
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sandeep TyagiJacques H Grosset
May 20, 2015·Antimicrobial Agents and Chemotherapy·Benoit Lechartier, Stewart T Cole
Dec 17, 2015·Chemical Communications : Chem Comm·B RühleJ I Zink
Feb 4, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Bastian RühleJeffrey I Zink
Sep 23, 2016·ACS Applied Materials & Interfaces·Anyanee KamkaewWeibo Cai
Oct 7, 2016·Physical Chemistry Chemical Physics : PCCP·Seishi Shimizu, Nobuyuki Matubayasi
Dec 10, 2016·ACS Applied Materials & Interfaces·Jing TuAlexander Kros
Jan 14, 2017·Journal of the American Chemical Society·Jing WeiDongyuan Zhao
Mar 24, 2017·The European Respiratory Journal·Margareth DalcolmoGiovanni B Migliori
Apr 25, 2017·Journal of the American Chemical Society·Bastian RuehleJeffrey I Zink
May 20, 2017·Science·Avinash PatelAnthony A Hyman
Jun 14, 2017·ACS Applied Materials & Interfaces·Cheng-Chung ChouChung-Yuan Mou

❮ Previous
Next ❯

Citations

May 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cuiyan HanWenquan Zhu
Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Evelyn C S SantosCélia M Ronconi
Aug 8, 2020·Frontiers in Chemistry·Vanitha SelvarajanPui Lai Rachel Ee
Dec 17, 2020·Pharmaceutics·Luíse L ChavesSalette Reis
Nov 2, 2020·Colloids and Surfaces. B, Biointerfaces·Sandra Montalvo-QuirósJose L Luque-Garcia
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marjan MotieiPetr Sáha
May 15, 2019·Accounts of Chemical Research·Wei ChenJeffrey I Zink
Jul 30, 2019·Journal of the American Chemical Society·Wei ChenEllen M Sletten
Oct 30, 2019·ACS Applied Materials & Interfaces·Liping RuanJeffrey I Zink
Jun 15, 2019·ACS Applied Materials & Interfaces·Qi YanYanjun Zhao
Aug 29, 2021·Pharmaceutics·Do-Hyun KimJaeh-Wi Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
K J Seung
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
Jung-Wan YooTae Sun Shim
Journal of Controlled Release : Official Journal of the Controlled Release Society
Haijiao ZhangZheng Jiao
American Journal of Respiratory and Critical Care Medicine
Kwonjune J SeungPaul Farmer
© 2022 Meta ULC. All rights reserved