Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery

Biomaterials Science
Suhair SunoqrotPhillip B Messersmith

Abstract

Nanoparticle-mediated drug delivery has demonstrated great potential to treat various diseases especially cancer. However, there is an unmet need for the scalable synthesis of multifunctional nanoparticles to meet the complex challenges of drug delivery. Here we show that we can synthesize nanoparticles from the polyphenol quercetin, which can be conveniently functionalized with ligands and drug molecules by simple mixing under ambient conditions. Nanoparticles (∼30-40 nm in diameter) were formed by oxidative self-polymerization of quercetin in alkaline buffer (pH 9). The reactivity of oxidized polyphenols was exploited to immobilize amine-terminated methoxy poly(ethylene glycol) on the nanoparticles' surface for steric stability, followed by loading with doxorubicin as a model drug. Surface modification of the nanoparticles was confirmed by X-ray Photoelectron Spectroscopy. An antioxidant assay showed that the nanoparticles retained some antioxidant activity. The nanoparticles were readily internalized by KB cells via an endo-lysosomal pathway. Doxorubicin-loaded nanoparticles showed a drug loading of 35.6 ± 4.9% w/w with a loading efficiency of 88.9 ± 12.4%, sustained drug release, and potent cytotoxicity in vitro. Our findin...Continue Reading

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Citations

Oct 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Suhair SunoqrotHiba Zalloum
Oct 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María D Navarro-HortalJosé L Quiles
Jun 22, 2021·Food & Function·Xinlong ZangXuehong Chen
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Biswajit ParhiSarat K Swain

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Methods Mentioned

BETA
dynamic
transmission
X-ray
flow cytometry
NMR

Software Mentioned

ImageJ
MultiPak
Zen
Graphpad Prism

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