Facile synthesis of gold nanorods/hydrogels core/shell nanospheres for pH and near-infrared-light induced release of 5-fluorouracil and chemo-photothermal therapy

Colloids and Surfaces. B, Biointerfaces
Hui JinZonghua Wang

Abstract

We described a facile synthesis of pH and near-infrared (NIR) light dual-sensitive core/shell hybrid nanospheres, consisting of gold nanorods (GNR) as the core and poly(N-isopropylacrylamide-co-methacrylic acid) as the shell, p(NIPAM-MAA). The resultant GNR/p(NIPAM-MAA) nanospheres showed a core/shell structure, with an average diameter of ∼110nm and a strong longitudinal surface plasmon band at NIR region. Due to the photothermal effect of GNR and pH/thermal-sensitive volume transition of p(NIPAM-MAA) hydrogels, the nanospheres with loading of 5-fluorouracil (5-FU) by electrostatic interactions were developed as a smart carrier for pH- and photothermal-induced release of 5-FU. Experimental results testified that the cumulative release of 5-FU from nanospheres was markedly increased in a mild acidic medium. Moreover, a NIR light (808nm) irradiation triggered a greater and faster release of 5-FU, which was further testified by relevant results from in vitro cytotoxicity assay, in vivo tumor growth inhibition and histological images of ex vivo tumor sections. These results revealed significant applications of GNR/p(NIPAM-MAA) nanospheres in controlled release of anticancer agents and photothermal ablation therapy of tumor tissues...Continue Reading

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Citations

Jul 14, 2017·Nanomedicine·Geoffrey A PieterszKarlheinz Peter
Dec 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingan YuWei Li
Jan 30, 2020·Archives of Pharmacal Research·Jin Kook KangKyung Taek Oh
Jun 13, 2016·Colloids and Surfaces. B, Biointerfaces·Shenna ChenXuanyong Liu
May 11, 2021·Frontiers in Pharmacology·Shengnan LiaoJinfeng Liao
Jul 12, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Xianyu SongHonglai Liu

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