Facile synthesis of polymeric fluorescent organic nanoparticles based on the self-polymerization of dopamine for biological imaging

Materials Science & Engineering. C, Materials for Biological Applications
Yingge ShiYen Wei

Abstract

Polymeric fluorescent organic nanoparticles (polymer-FONs) have raised considerable research attention for biomedical applications owing to their advantages as compared with fluorescent inorganic nanoparticles and small organic molecules. In this study, we presented an efficient, facile and environment-friendly strategy to produce polymer-FONs, which relied on the self-polymerization of dopamine and polyethyleneimine (PEI) in rather mild conditions. To obtain the final polymer-FONs, aldehyde group-containing copolymers (named as poly(UA-co-PEGMA)) were synthesized by reversible addition-fragmentation chain-transfer polymerization using polyethylene glycol methyl ether methacrylate (PEGMA) and 1-undecen-10-al (UA) as monomers. The dopamine was conjugated onto poly(UA-co-PEGMA) through a multicomponent reaction between UA and dopamine to obtain poly(UA-co-PEGMA)-DA, which was further utilized for preparation of polymer-FONs through self-polymerization of dopamine and PEI. (1)H nuclear magnetic resonance, Fourier transform infrared spectroscopy, transmission electron microscopy and fluorescence spectroscopy were employed to characterize the structure, morphology, compositions and optical properties of these polymer-FONs. Cell viab...Continue Reading

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Citations

Feb 2, 2019·Journal of Biomedical Materials Research. Part a·Shiyu ChenYumin Yang
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hongye HuangYen Wei
Jan 7, 2021·International Journal of Molecular Sciences·Yale Yue, Xiao Zhao
Nov 21, 2020·Nanomaterials·Alexandra Mavridi-PrinteziMarco Montalti
Mar 10, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Lili GuoYen Wei
Dec 7, 2018·ACS Applied Materials & Interfaces·Jounghyun YooWoosung Kwon

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