Facile thiolytic removal of the o-nitrophenylsulphenyl amino-protecting group

International Journal of Peptide and Protein Research
M SternM Fridkin

Abstract

2-Mercaptopyridine was used to effect the selective, mild and efficient cleavage of the o-nitrophenylsulphenyl amino-protecting group from several amino acids and peptides. By utilization of this reagent a stepwise synthesis of the tetrapeptide Thr-Lys-Leu-Arg([Leu3]tuftsin) was successfully achieved. The potential use of 2-mercaptopyridine in mechanized peptide synthesis via the polymeric reagents approach is discussed.

References

Apr 21, 1976·Helvetica Chimica Acta·M Juillerat, J P Bargetzi
May 22, 1968·Journal of the American Chemical Society·M FridkinE Katchalski

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Citations

May 1, 1981·International Journal of Peptide and Protein Research·M SternM Fridkin
Aug 27, 2019·Chemistry : a European Journal·Tsubasa InokumaKen-Ichi Yamada
Mar 30, 2010·Bioconjugate Chemistry·Adva BitonEylon Yavin

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