Facilitated Ca2+ homeostasis and attenuated myocardial autophagy contribute to alleviation of diabetic cardiomyopathy after bariatric surgery

American Journal of Physiology. Heart and Circulatory Physiology
Xin HuangSanyuan Hu

Abstract

Bariatric surgery has been reported to relieve diabetic cardiomyopathy (DCM) effectively. However, the mechanisms remain largely unknown. To determine the effects of bariatric surgery on DCM via modulation of myocardial Ca2+ homeostasis and autophagy, sleeve gastrectomy (SG), duodenal-jejunal bypass (DJB), and sham surgeries were performed in diabetic rats induced by high-fat diet and a low dose of streptozotocin. Cardiac remodeling was assessed by a series of morphometric and histological analyses. Transthoracic echocardiography and hemodynamic measurements were performed to determine cardiac function. Ca2+ homeostasis was evaluated by measuring Ca2+ transients with fura-2 AM in isolated ventricular myocytes along with detection of the abundance of Ca2+ regulatory proteins in the myocardium. Myocardial autophagic flux was determined by expression of autophagy-related proteins in the absence and presence of chloroquine. Both SG and DJB surgery alleviated DCM morphologically and functionally. Ca2+ transients exhibited a significantly higher amplitude and faster decay after SG and DJB, which could be partially explained by increased expression of ryanodine receptor 2, sarco(endo)plasmic reticulum Ca2+-2ATPase, 12.6-kDa FK506-bind...Continue Reading

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Citations

Apr 16, 2019·PloS One·Aiko ItoSatoshi Okumura
Jul 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Kate L WeeksJulie R McMullen
Mar 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Leslie M OgilvieJeremy A Simpson
Aug 17, 2021·Physiological Reviews·Willis K SamsonCarol Ann Remme

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Methods Mentioned

BETA
gastric bypass
PCR
electrophoresis

Software Mentioned

PASW Statistics
ImageLab
ImagePro Plus
SPSS

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