Facilitated Water Transport through Graphene Oxide Membranes Functionalized with Aquaporin-Mimicking Peptides

Advanced Materials
Chang Seon LeeYun Jung Lee

Abstract

Water purification by membranes is widely investigated to address concerns related to the scarcity of clean water. Achieving high flux and rejection simultaneously is a difficult challenge using such membranes because these properties are mutually exclusive in common artificial membranes. Nature has developed a method for this task involving water-channel membrane proteins known as aquaporins. Here, the design and fabrication of graphene oxide (GO)-based membranes with a surface-tethered peptide motif designed to mimic the water-selective filter of natural aquaporins is reported. The short RF8 (RFRFRFRF, where R and F represent arginine and phenylalanine, respectively) octapeptide is a concentrated form of the core component of the Ar/R (aromatic/arginine) water-selective filter in aquaporin. The resulting GO-RF8 shows superior flux and high rejection similar to natural aquaporins. Molecular dynamics simulation reveal the unique configuration of RF8 peptides and the transport of water in GO-RF8 membranes, supporting that RF8 effectively emulates the core function of aquaporins.

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Citations

Dec 8, 2019·Mikrochimica Acta·Shubhi JoshiAvneet Saini
Jun 6, 2019·Science and Technology of Advanced Materials·Peter Ozaveshe OvirohTien-Chien Jen
May 29, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Peter Ozaveshe OvirohSina Karimzadeh
Aug 8, 2019·Environmental Science & Technology·Lina ZhangBaoliang Chen
Sep 10, 2021·Chemical Society Reviews·Yanan LiuZhongyi Jiang
Jan 12, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qisheng YeXiaoying Zhu

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