Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat

Gastroenterology
Min Zhuo, G F Gebhart

Abstract

Noxious inputs from somatic tissue are subject to biphasic descending modulation from the rostroventral medulla (RVM). In the present study, we investigated descending facilitatory and inhibitory influences from the RVM on a visceral nociceptive reflex. The visceromotor response (VMR), a contraction of peritoneal musculature during noxious colorectal distention (80 mm Hg, 20 seconds), was quantified as the integrated electromyogram. At 22 sites in the RVM, electrical stimulation produced biphasic effects, facilitating the VMR at low (5, 10, and 25 microA) and inhibiting it at greater (>50 microA) intensities of stimulation. Electrical stimulation at all intensities tested (5-200 microA) in other sites in the RVM only inhibited (30 sites) or only facilitated (12 sites) the VMR to colorectal distention. Activation of glutamatergic receptors in the RVM replicated the effects of electrical stimulation. Reversible blockage (intraspinal lidocaine injection) or irreversible transection of spinal funiculi revealed that descending facilitatory influences from the RVM were conveyed in the ventrolateral/ventral funiculus, whereas descending inhibitory influences were contained in the dorsolateral funiculi. Spinal visceral nociceptive refl...Continue Reading

Citations

Nov 10, 2006·Molecular Pain·Hendrik W SteenlandMin Zhuo
Jan 9, 2009·Inflammatory Bowel Diseases·Klaus BielefeldtDavid G Binion
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
May 16, 2009·European Journal of Pain : EJP·Raul SanojaFernando Cervero
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Muriel LaraucheYvette Taché
Mar 23, 2017·Molecular Pain·Min Zhuo
Mar 30, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R P WillertA R Hobson
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P AnandL van Oudenhove
Jul 8, 2011·Digestive Diseases·Robin C Spiller
Jan 22, 2009·Pain·Charles H Knowles, Qasim Aziz
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Aug 25, 2006·Journal of Neurophysiology·Thaddeus S BrinkPeggy Mason
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Feb 4, 2006·The Journal of Physiology·Ezidin G Kaddumi, Charles H Hubscher
Jun 8, 2007·Molecular Pain·Min Zhuo
May 10, 2017·Journal of Acupuncture and Meridian Studies·Salvador Quiroz-GonzálezIsmael Jiménez Estrada
Mar 12, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jinghong ChenJohn H Winston

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