PMID: 9438802Jan 23, 1998Paper

Facilitation and inhibition of the acoustic startle reflex in the rat after a momentary increase in background noise level

Behavioral Neuroscience
J R IsonS B Schwarzkopf

Abstract

Small increments in background noise were shown to increase the amplitude of a subsequently elicited acoustic startle reflex (ASR) in rats by as much as 100% under optimal conditions. Increment lead time (5-160 ms) and level (1.5-15 dB), initial noise level (30-70 dB), startle level (95-125 dB), number of test days (1-5), and drug condition (diazepam or saline ip) were varied in 6 experiments. Prepulse facilitation (PPF), measured by difference scores, was greatest for intermediate increments (3 dB) and lead times (20-40 ms) and was replaced by prepulse inhibition (PPI) for higher values, especially in the later test days. Diazepam reduced baseline ASR and diminished PPI, but it did not affect PPF. These data argue against hypotheses that attribute PPF of this sort to either temporal integration within the ASR pathways or to the elicitation of a nonspecific arousal reaction by the prepulse.

Citations

Jun 16, 2004·Behavioural Brain Research·Claudia F PlappertHans-Ulrich Schnitzler
Dec 9, 2000·Physiology & Behavior·J W BłaszczykB Sadowski
Feb 24, 2006·Behavioral Neuroscience·Claudia F PlappertPeter K D Pilz
Nov 16, 2013·Noise & Health·Jennifer CampoloRichard Salvi
Nov 17, 2009·Behavioural Brain Research·Sandra L McFaddenRussell E Morgan
Aug 8, 2009·Physiology & Behavior·Bernhard H GaesePeter K D Pilz
Sep 12, 2014·The European Journal of Neuroscience·Duncan A A MacLarenStewart D Clark
Mar 10, 2015·Frontiers in Neurology·Kelly E RadziwonRichard J Salvi
Jul 22, 2016·Perceptual and Motor Skills·Ryoji Nishiyama, Hiroyuki Iso

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