Abstract
The influence of substance P 3 (microgram/kg) and (+)-tubocurarine (850 micrograms/kg) on the Bezold-Jarisch reflex in urethane-anaesthetized rats was studied. The Bezold-Jarisch reflex was induced by the 5-HT3 receptor agonist phenylbiguanide (0.3, 1, 3 and 10 micrograms/kg i.v.) and by capsaicin (10 micrograms/kg i.v.). The 5-HT3 receptor antagonist ondansetron (10 micrograms/kg) abolished the phenylbiguanide- but not the capsaicin-stimulated bradycardia, indicating that phenylbiguanide and capsaicin act via different trigger mechanisms (5-HT3 receptor-dependent and -independent, respectively). Substance P significantly potentiated the phenylbiguanide- but not the capsaicin-induced decrease in heart rate. Also, when the phenylbiguanide-induced response was amplified by substance P, it was abolished by ondansetron. (+)-Tubocurarine inhibited the phenylbiguanide-induced bradycardia, but did not affect the capsaicin-stimulated decrease in heart rate. Our results demonstrate that substance P potentiates but (+)-tubocurarine inhibits the 5-HT3 receptor-mediated Bezold-Jarisch reflex. Both effects are probably due to direct influences of the drugs on the 5-HT3 receptors on sensory vagal nerves in the heart.
References
Mar 1, 1991·British Journal of Pharmacology·N R NewberryM J Gilbert
Aug 14, 1992·European Journal of Pharmacology·N R NewberryD G Grahame-Smith
Mar 2, 1990·Neuroscience Letters·J A PetersJ J Lambert
Oct 18, 1991·Science·A V MaricqD Julius
Sep 1, 1990·Trends in Pharmacological Sciences·M MousliY Landry
Aug 1, 1990·British Journal of Pharmacology·R G BogleA G Ramage
Jan 19, 1988·European Journal of Pharmacology·G Reiser, B Hamprecht
Feb 6, 1989·Brain Research·G Reiser, B Hamprecht
Jun 29, 1989·Nature·V DerkachR A North
Jun 1, 1988·British Journal of Pharmacology·A ButlerM B Tyers
Apr 10, 1980·Nature·T HökfeltM Schultzberg
May 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·J R Fozard
Jan 1, 1983·Journal of the American College of Cardiology·A L Mark
Aug 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·M BarannH Bönisch
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·P M PilowskyJ P Chalmers
Mar 1, 1995·British Journal of Pharmacology·C H GillJ J Lambert
May 1, 1995·Pharmacology & Therapeutics·P R Saxena
May 26, 1995·European Journal of Pharmacology·B MalinowskaW Buczko
Feb 1, 1993·British Journal of Pharmacology·H BönischM Göthert
Jun 1, 1993·Journal of Neurochemistry·M B EmeritM Hamon
Sep 1, 1994·Journal of the Autonomic Nervous System·K SaitoA Kitabatake
Citations
Feb 20, 2003·European Journal of Pharmacology·David PascualMaría Isabel Martín
Jun 18, 2003·Respiratory Physiology & Neurobiology·Jay K HermanGerald E Bisgard
May 8, 1999·The British Journal of Dermatology·U Wollina
Feb 24, 2012·Pharmacological Reports : PR·Sebastian Ł LupińskiBarbara Malinowska
Mar 19, 2003·British Journal of Pharmacology·Grzegorz GodlewskiBarbara Malinowska
Dec 29, 1998·The Journal of Trauma·R J GuyG J Cooper
Aug 30, 2008·Hypertension·Colleen J ThomasRobyn L Woods
Feb 13, 2020·Pharmacological Reports : PR·Manfred GöthertEberhard Schlicker
May 16, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·H BönischE Schlicker