Facilitation of facial nerve regeneration using chitosan-β-glycerophosphate-nerve growth factor hydrogel

Acta Oto-laryngologica
Xiuhua ChaoHaibo Wang

Abstract

Conclusion C/GP hydrogel was demonstrated to be an ideal drug delivery vehicle and scaffold in the vein conduit. Combined use autologous vein and NGF continuously delivered by C/GP-NGF hydrogel can improve the recovery of facial nerve defects. Objective This study investigated the effects of chitosan-β-glycerophosphate-nerve growth factor (C/GP-NGF) hydrogel combined with autologous vein conduit on the recovery of damaged facial nerve in a rat model. Methods A 5 mm gap in the buccal branch of a rat facial nerve was reconstructed with an autologous vein. Next, C/GP-NGF hydrogel was injected into the vein conduit. In negative control groups, NGF solution or phosphate-buffered saline (PBS) was injected into the vein conduits, respectively. Autologous implantation was used as a positive control group. Vibrissae movement, electrophysiological assessment, and morphological analysis of regenerated nerves were performed to assess nerve regeneration. Results NGF continuously released from C/GP-NGF hydrogel in vitro. The recovery rate of vibrissae movement and the compound muscle action potentials of regenerated facial nerve in the C/GP-NGF group were similar to those in the Auto group, and significantly better than those in the NGF grou...Continue Reading

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Citations

Apr 8, 2017·Experimental & Molecular Medicine·Pan JinXingdong Zhang
Apr 26, 2019·Frontiers in Cellular Neuroscience·A BoeckerL Harhaus
Mar 27, 2020·Neural Regeneration Research·Yanjun XieMichael J Brenner
Jun 10, 2020·The Journal of Physiological Sciences : JPS·Motoyasu SugiyamaSeiji Kakehata
May 27, 2021·Advances in Pharmacological and Pharmaceutical Sciences·Pouria Rahmanian-DevinVahid Reza Askari
Aug 3, 2021·Frontiers in Neuroscience·Giuseppe AlastraGiovanni Tosi

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