PMID: 2827823Nov 1, 1987Paper

Facilitation of frog neuromuscular transmission by sodium fluoride

British Journal of Pharmacology
T Hattori, H Maehashi

Abstract

1. The effects of sodium fluoride (NaF, 5 mM) alone or in combination with theophylline (1.5 mM) or imidazole (1.5 mM) on the amplitude of the endplate potential (e.p.p.), frequency of the miniature endplate potential (m.e.p.p.), and the quantal content of the e.p.p. of bullfrog muscle were investigated. The effects of forskolin (1 microM) and papaverine (1 microM) on the m.e.p.p. frequency were also studied. 2. NaF caused an increase of 22% in the amplitude of the e.p.p. This NaF-induced increase was enhanced by theophylline (to 51%) and reduced by imidazole (to 10%). 3. Papaverine (0.1-3 microM) increased the frequency of m.e.p.ps. Forskolin at 1 microM raised the m.e.p.p. frequency by 13%. The effect was increased to 31% by 1 microM papaverine. NaF also raised the m.e.p.p. frequency by 90%. This action too was increased by theophylline (2.6 fold) and by papaverine (2.1 fold); however, it was reduced by imidazole (1.3 fold). 4. NaF increased the quantal content of the e.p.p. by 28%. This effect was enhanced by theophylline to 44%, while it was diminished by imidazole. 5. These results suggest that an increase in the transmitter release via an elevation of cyclic AMP may be involved in the facilitation of neuromuscular transmi...Continue Reading

References

Jun 1, 1978·Neuropharmacology·K KaibaraA G Karczmar
Jan 1, 1986·Japanese Journal of Pharmacology·T Hattori, H Maehashi
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·A L Goldberg, J J Singer
Feb 1, 1981·Anesthesia and Analgesia·F G Standaert, K L Dretchen
Jun 28, 1954·The Journal of Physiology·J DEL CASTILLO, B KATZ
Aug 1, 1956·The American Journal of Physiology·R W GERARD, K KOKETSU
Jul 1, 1959·Journal of Neurophysiology·A TAKEUCHI, N TAKEUCHI
May 1, 1961·The Journal of General Physiology·C P Bianchi

❮ Previous
Next ❯

Citations

Oct 15, 1991·European Journal of Pharmacology·P E Light, S J Publicover
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Travis J NickelsDavid F Wilson
Apr 1, 1990·Journal of Neurobiology·J M Dubinsky, G D Fischbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.