PMID: 8950313Jan 1, 1996Paper

Facilitation of memory retrieval by the "anti-addictive" alkaloid, ibogaine

Life Sciences
P Popik

Abstract

Anecdotal observations in humans indicate that indole alkaloid ibogaine may have anti-addictive properties. It has been suggested that the therapeutic action of ibogaine may depend upon facilitated access to the past experiences, purportedly influencing the initiation of drug addiction. To determine if ibogaine may facilitate memory retrieval, rats were trained in the Morris maze spatial navigation task. It has been found that ibogaine (0.25 or 2.5 mg/kg) or O-desmethyl-ibogaine (2.5 mg/kg) but not t-Butyl ibogaine, administered just before the test trial, facilitated spatial memory retrieval compared to rats receiving placebo treatment. It is concluded that although previously described NMDA receptor antagonistic properties of ibogaine may represent a locus for at least some of its actions, other mechanisms, involving facilitation of memory retrieval may be of importance for its anti-addictive effects.

References

May 18, 1989·Nature·R G Morris, D J Willshaw
Jan 1, 1995·Life Sciences·R H MachS R Childers
May 1, 1995·Pharmacology, Biochemistry, and Behavior·R P KesnerK Amann
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·A H RezvaniY W Lee
Mar 25, 1996·Brain Research·S D GlickI M Maisonneuve

❮ Previous
Next ❯

Citations

Feb 13, 2001·Behavioural Brain Research·P PopikJ Vetulani
Nov 9, 2002·Journal of Psychoactive Drugs·Marlene Dobkin de RiosJohn R Baker
Jan 25, 2012·Journal of Forensic Sciences·Kenneth R AlperJames R Gill
Dec 28, 2011·Journal of Ethnopharmacology·Kenneth AlperHenry Sershen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmacology, Biochemistry, and Behavior
S HelsleyJ C Winter
The American Journal on Addictions
Kenneth R AlperJ Bastiaans
Journal of Ethnopharmacology
Kenneth R AlperH Sershen
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Mohammad MasoomiFatemeh Mirzaeepour
© 2021 Meta ULC. All rights reserved