Facilitation of mossy fibre-driven spiking in the cerebellar nuclei by the synchrony of inhibition

The Journal of Physiology
Yeechan Wu, Indira M Raman

Abstract

Large premotor neurons of the cerebellar nuclei (CbN cells) integrate synaptic inhibition from Purkinje neurons and synaptic excitation from mossy fibres to generate cerebellar output. We find that mossy fibre inputs to CbN cells generate unitary AMPA receptor EPSCs of ∼1 nS that decay in ∼1 ms and mildly voltage-dependent NMDA receptor EPSCs of ∼0.6 nS that decay in ∼7 ms. A few hundred mossy fibres active at a few tens of spikes s-1 must converge on CbN cells to generate physiological CbN spike rates (∼60 spikes s-1 ) during convergent inhibition from spontaneously active Purkinje cells. Dynamic clamp studies in cerebellar slices from weanling mice demonstrate that synaptic excitation from mossy fibres becomes more effective at increasing the rate of CbN cell spiking when the coherence (synchrony) of convergent inhibition is increased. Large projection neurons of the cerebellar nuclei (CbN cells), whose activity generates movement, are inhibited by Purkinje cells and excited by mossy fibres. The high convergence, firing rates and strength of Purkinje inputs predict powerful suppression of CbN cell spiking, raising the question of what activity patterns favour excitation over inhibition. Recording from CbN cells at near-physio...Continue Reading

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Citations

Aug 18, 2018·Neurochemical Research·J PickfordZ I Bashir
Oct 22, 2019·Frontiers in Computational Neuroscience·Alice GeminianiClaudia Casellato
Aug 11, 2017·The Journal of Physiology·Marion Najac, Indira M Raman
Jul 2, 2021·Frontiers in Neural Circuits·Moritoshi HironoYuchio Yanagawa
Jul 12, 2020·Neuroscience·Ayesha R ThanawallaEiman Azim

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