PMID: 7019985Oct 1, 1980Paper

Facilitation of mounting behavior in male rats by intracranial injections of luteinizing hormone-releasing hormone

Regulatory Peptides
D M Dorsa, E R Smith

Abstract

Luteinizing hormone-releasing hormone (LH-RH) administration has been reported to facilitate male sex behavior. This laboratory has previously reported development of the 'mounting test', a paradigm which reflects sexual arousal mechanisms. We have used this test to study the interaction of LH-RH with the central components of male copulatory behavior in the rat. Sixty 90-day-old Long-Evans male rats were screened for sex behavior and divided into 5 treatment groups. For all mounting tests, a local anesthetic was applied to the penis and mounts were scored during a 15-min exposure to a stimulus female. The animals were given 3 successive weekly tests. By the final test, a significant decrement in mounting behavior was noted, and those males given 50 ng LH-RH i.c.v. displayed more mounting in this test than animals given either no treatment or saline (P less than 0.01). A slight but significant (P less than 0.05) enhancement of performance was also noted in peptide-treated rats in test I. There was no significant difference in any of the tests between animals given lateral cerebroventricular (i.c.v.) injections of 2 microliter acidified saline and those given no treatment. When blood samples were taken from similarly treated ani...Continue Reading

References

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Citations

Jan 1, 1986·Neuroscience and Biobehavioral Reviews·E M Kostarczyk
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Jan 1, 1994·Psychoneuroendocrinology·M Meredith, G Fernandez-Fewell
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