Facilitation of short-term social memory by ethanol in rats is mediated by dopaminergic receptors

Behavioural Brain Research
Rui D S PredigerReinaldo N Takahashi

Abstract

Ethanol is a drug that has apparently opposite effects on memory processes depending on when it is given relative to the task, as well as the nature of the task under study. Recently, we demonstrated that acute low doses of ethanol (0.5 and 1.0 g/kg, i.p.) improve the short-term social memory in rats in a specific and time-dependent manner, and that this action is, at least in part, related to opioid, but not to muscarinic receptors. In the present study, we evaluated whether this positive effect of ethanol on the short-term memory of rats is related to a reducing impact of interference during the task through two different procedures: the introduction of an unfamiliar juvenile rat or the placing of the adult rat in the open field during the inter-exposure interval. The actions of reserpine (0.4 and 0.8 mg/kg, s.c.), haloperidol (0.05 and 0.2 mg/kg, i.p.), the D2 receptor antagonist sulpiride (20.0 and 50.0 mg/kg, i.p.) and the D1 receptor antagonist SCH 23390 (0.01 and 0.03 mg/kg, s.c.) and their interaction with ethanol (1.0 g/kg, i.p.) in relation to short-term memory were also studied. The administration of ethanol (1.0 g/kg, i.p.), immediately after the end of the first presentation, did not reduce the effect on social mem...Continue Reading

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Citations

Sep 2, 2008·Psychopharmacology·Michael J SpinettaTimothy Schallert
Jan 17, 2016·Epilepsy & Behavior : E&B·Mark William LopesRodrigo Bainy Leal
Jul 7, 2011·Behavioural Processes·Paula Jaqueline MouraGilberto Fernando Xavier
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Aug 19, 2009·Annals of the New York Academy of Sciences·Rui D S PredigerReinaldo N Takahashi
Feb 22, 2005·Neuroscience Letters·Rui D S Prediger, Reinaldo N Takahashi
Oct 19, 2006·Life Sciences·Ameneh RezayofMohammad-Reza Zarrindast
Jan 28, 2006·European Journal of Pharmacology·Rui D S PredigerReinaldo N Takahashi
Aug 17, 2005·Drug and Alcohol Dependence·Héctor M ManriqueCarlos M G Aragon
Dec 12, 2012·Neurobiology of Learning and Memory·Mohammad Reza ZarrindastShamseddin Ahmadi
Jun 1, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P J MouraG F Xavier
Dec 29, 2020·Brain Research Bulletin·Débora Dalla VecchiaRoberto Andreatini

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