Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides

Peptides
K JhamandasH-Y T Yang

Abstract

Neuropeptide FF and related synthetic amidated peptides have been shown to elicit sustained anti-nociceptive responses and potently augment spinal anti-nociceptive actions of spinal morphine in tests of thermal and mechanical nociception. Recent studies have described the occurrence of another octapeptide, neuropeptide SF (NPSF) in the spinal cord and the cerebrospinal fluid and demonstrated its affinity for the NPFF receptors. This study examined the effects of NPSF and two putative precursor peptides, EFW-NPSF and NPAF, on the spinal actions of morphine in normal and opioid tolerant rats using the tailflick and pawpressure tests. In normal rats, NPSF demonstrated weak intrinsic activity but sub-effective doses of the peptide significantly increased the magnitude and duration of spinal morphine anti-nociception in both tests. A low-dose of NPSF also augmented the spinal actions of a delta receptor agonist, deltorphin. The morphine-potentiating effect of NPSF was shared by EFW-NPSF and the octadecapeptide NPAF. In animal rendered tolerant by continuous intrathecal infusion of morphine for 6 days, low dose NPSF itself elicited a significant anti-nociceptive response and potently increased morphine-induced response in both tests....Continue Reading

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Citations

Dec 10, 2013·Regulatory Peptides·Miklós JászberényiGyula Telegdy
Dec 1, 2009·Peptides·Franck TalmontCatherine Mollereau
Jun 23, 2009·Behavioural Brain Research·Brandon A Newmyer, Mark A Cline
Oct 24, 2007·Peptides·Richard J Bodnar
Sep 15, 2007·Neuropeptides·Hsiu-Ying T YangMichael J Iadarola
Aug 31, 2010·BioFactors·Lionel MoulédousJean-Marie Zajac
Aug 1, 2006·Hormones and Behavior·Lance J Kriegsfeld
Jun 14, 2012·Brain Research Bulletin·Anita KovácsLászló Lénárd
Oct 18, 2014·Frontiers in Endocrinology·Safia Ayachi, Frédéric Simonin

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