PMID: 7370747Apr 21, 1980Paper

Facilitation of spinal motoneurone excitability by 5-hydroxytryptamine and noradrenaline

Brain Research
S R White, R S Neuman

Abstract

The effects of iontophoretic application of 5-hydroxytryptamine (5-HT) and noradrenaline (NA) on lumbar motoneurone excitability were examined. 5-HT and NA produced long-lasting changes in motoneurone excitability as revealed by decreased threshold for glutamate-evoked motoneurone action potentials, increased rate of motoneurone firing evoked by suprathreshold amounts of glutamate and increased amplitude of ventral root and dorsal root evoked motoneurone field potentials. Neither 5-HT nor NA directly evoked motoneurone action potentials in the absence of other excitatory input. The 5-HT antagonist, methergoline, reduced glutamate-evoked motoneurone activity and prevented 5-HT, but not NA, facilitation of glutamate-evoked activity. These results suggest that 5-HT and NA enhance the effects of excitatory inputs to spinal motoneurones by actions on separate receptors.

References

Oct 1, 1979·Electroencephalography and Clinical Neurophysiology·R S Neuman, S R White
Jun 15, 1979·Brain Research·R B McCall, G K Aghajanian
Jan 1, 1976·Acta Physiologica Scandinavica·I EngbergK Kadzielawa
Nov 1, 1968·European Journal of Pharmacology·J W PhillisD H York
Mar 1, 1964·Archives of Oral Biology·J D ECCLES

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Citations

Dec 1, 1987·Cellular and Molecular Neurobiology·S NedergaardJ A Flatman
Jan 1, 1993·Psychopharmacology·C A MorganD S Charney
Jul 20, 1981·Brain Research·S J Fung, C D Barnes
Sep 11, 1981·European Journal of Pharmacology·J HeymB L Jacobs
Feb 26, 1982·European Journal of Pharmacology·C P Vandermaelen, G K Aghajanian
Jun 16, 1982·European Journal of Pharmacology·R S Neuman, S R White
Oct 10, 1996·European Journal of Pharmacology·M GozariuJ C Willer
Jan 1, 1986·Neuropharmacology·L E Tremblay, P J Bedard
May 1, 1985·Pharmacology, Biochemistry, and Behavior·T L Yaksh
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·R B McCall

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