Facilitation of striatal acetylcholine release by dopamine D1 receptor stimulation: involvement of enhanced nitric oxide production via neurokinin-2 receptor activation

Neuroscience
Régis SteinbergP Soubrié

Abstract

The regulation of striatal cholinergic function by dopamine D1 receptor activation was examined in vivo in urethane-anaesthetized rats with microdialysis probes. Extracellular acetylcholine levels were enhanced by activation of D1 receptors either directly by a striatal application of the D1 receptor agonist (+)-SKF-38393 (3 microM) or indirectly by the release of dopamine evoked by striatal application of neurotensin (0.1 microM) under D2 receptor blockade. SR 144190, a new potent and selective non-peptide neurokinin-2 receptor antagonist (0.03-1 mg/kg, i.p.), dose-dependently reduced the acetylcholine release induced by (+)-SKF-38393 or neurotensin. Furthermore, intrastriatal application of SR 144190 (1 nM) blocked the increase in acetylcholine release induced by the local application of (+)-SKF-38393 (3 microM), neurokinin A (1 microM) or substance P (1 microM). Finally, a role for nitric oxide in mediating the effects of D1 neurokinin-2 receptor activation on acetylcholine release is proposed since local infusion of the competitive inhibitor of nitric oxide synthase, N(G)-monomethyl-L-arginine (0.01-10 microM), blocked the increase in acetylcholine release induced by (+)-SKF-38393 (3 microM), neurotensin (0.1 microM) or neu...Continue Reading

References

Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Jan 3, 1991·European Journal of Pharmacology·F PetitetJ C Beaujouan
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Sep 21, 1990·European Journal of Pharmacology·G DamsmaH C Fibiger
Jul 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·H PrastA Philippu
Jun 1, 1993·Journal of Neuroscience Research·G LonartK M Johnson
Jun 1, 1993·Journal of Neurochemistry·C J MussapE Burcher
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Jan 31, 1996·Neuroreport·M ShibataY Fukuuchi
Jan 1, 1997·Brain Research Bulletin·Y IkarashiY Maruyama

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Citations

Mar 14, 2000·Life Sciences·L FerraroT Antonelli
Apr 12, 2001·Neuroscience Letters·M BensaidF Oury-Donat
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen SammutAnthony R West
Aug 18, 2004·Neurochemistry International·Jan de Vente
Feb 17, 2018·Pharmaceutical Research·Willem Johan van den BrinkElizabeth Cunera Maria de Lange
Dec 12, 2001·Journal of Neurochemistry·M SaffroyJ C Beaujouan
Mar 3, 2019·Neurochemistry International·Samira Ztaou, Marianne Amalric
May 12, 2004·Peptides·Jean-Claude BeaujouanJacques Glowinski

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