PMID: 3746701May 1, 1986Paper

Facilitation of transmitter action on catecholamine output by cardiac glycoside in perfused adrenal gland of guinea-pig

The Journal of Physiology
Y NakazatoY Yamada

Abstract

Effects of K+ deprivation and ouabain on catecholamine secretion evoked by splanchnic nerve stimulation (5 Hz), ACh (10(-5) M) and/or excess K+ (56 mM) were studied in isolated and perfused adrenal glands of guinea-pig. Exposure to K+-free Locke solution initially reduced and later enhanced catecholamine secretion sequentially evoked by splanchnic nerve stimulation and ACh. The enhancement attained a maximum, 185% in magnitude of the corresponding control response at 35 min for splanchnic nerve stimulation and 135% at 65 min for ACh after the start of exposure to K+-free solution. Ouabain (10(-5) M) caused a larger increase in the evoked catecholamine section than K+ deprivation did. The maximum effect was obtained from 40 to 50 min after the start of exposure to ouabain in which the magnitude of responses to splanchnic nerve stimulation, excess K+ and ACh was about 500, 400 and 300% of each control response, respectively. The effect of ouabain on the evoked catecholamine secretion increased as the concentration of extracellular Na+ was increased from 25 to 154 mM, regardless of the kind of stimuli. The ouabain-induced enhancement in the evoked responses was reversibly inhibited by removing Ca2+ from, or by adding Mg2+, Co2+ or...Continue Reading

Citations

Aug 4, 2007·Progress in Neurobiology·Tamás L Török
Mar 1, 1992·Journal of Neurochemistry·E Satoh, Y Nakazato
Jul 3, 1999·Physiological Reviews·M P Blaustein, W J Lederer

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