PMID: 9533170Apr 9, 1998Paper

Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog

Progress in Neuro-psychopharmacology & Biological Psychiatry
J BruhwylerJ Géczy

Abstract

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differential reinforcement of response duration schedule in normal dogs. 3. The effects of citicoline on a stabilized performance were also measured in order to be able to differentiate specific memory effects from non specific influences on the motor, neuro-vegetative and motivational systems. 4. The results demonstrate that citicoline can exert facilitatory effects on learning and memory but also on retrieval processes. The complete absence of effects on the stabilized performance and on the motor, neuro-vegetative and motivational systems constitutes arguments in favour of a selectivity of action on the memory processes.

References

Sep 1, 1992·Brain Research. Brain Research Reviews·S E MolchanT Sunderland
Nov 1, 1980·Pharmacology, Biochemistry, and Behavior·P S McGuire, L S Seiden
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·J BruhwylerM Mercier

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Citations

Mar 11, 2005·Neurochemical Research·Rao Muralikrishna Adibhatla, J F Hatcher
Mar 30, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gary Landsberg
Jun 1, 2004·Acta Neuropsychiatrica·Ebrahim AbdollahianArash Javanbakht

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