PMID: 7516799Jan 1, 1994Paper

Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences

British Journal of Pharmacology
M G BelvisiC A Maggi

Abstract

1. Exogenous tachykinins modulate cholinergic neurotransmission in rabbit and guinea-pig airways. We have investigated the effect of selective tachykinin receptor agonists and antagonists on cholinergic neurotransmission evoked by electrical field stimulation (EFS) of bronchial rings in rabbit, guinea-pig and human airways in vitro to assess which type of tachykinin receptor is mediating this facilitatory effect. 2. Bronchial rings were set up for isometric tension recording. Contractile responses to EFS (60 V, 0.4 ms, 2 Hz for 10 s every min) and exogenous acetylcholine (ACh) were obtained and the effects of selective tachykinin agonists and antagonists were investigated. 3. In rabbit bronchi the endogenous tachykinins, substance P (SP) and neurokinin A (NKA) (10 nM) potentiated cholinergic responses to EFS (by 287.6 +/- 121%, P < 0.01 and 181.4 +/- 56.5%, P < 0.001 respectively). 4. The NK1 receptor selective agonist, [Sar9]SP sulphone (10 nM) evoked a maximal facilitatory action on cholinergic responses of 334.9 +/- 63% (P < 0.01) (pD2 = 8.5 +/- 0.06) an effect which was blocked by the selective NK1-receptor antagonist, CP 96,345 (100 nM) (P < 0.05) but not by the NK2 receptor antagonist, MEN 10,376 (100 nM). The NK2 recepto...Continue Reading

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Citations

Mar 1, 1995·Medicinal Research Reviews·L QuartaraC A Maggi
Sep 1, 1995·General Pharmacology·C A Maggi
Jul 16, 1997·European Journal of Pharmacology·T S SalehY S Medeiros
Oct 6, 1997·British Journal of Pharmacology·M M RiccioC P Page
Jan 11, 2003·British Journal of Pharmacology·Jonathan E PhillipsMichel R Corboz
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Jul 1, 1995·British Journal of Pharmacology·M BushfieldA M Naylor
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Jan 1, 1995·Peptides·M D Yohannan, P Ernsberger
Sep 22, 2007·Respiratory Physiology & Neurobiology·Radhika Kajekar, Allen C Myers
Sep 2, 2006·Vascular Pharmacology·Brendan J Canning
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Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SchuilingH Meurs
Oct 26, 2000·Neuropeptides·A LecciC A Maggi

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