Facility Volume and Survival in Nasopharyngeal Carcinoma

International Journal of Radiation Oncology, Biology, Physics
Emi J YoshidaZachary S Zumsteg

Abstract

Definitive treatment of nasopharyngeal carcinoma (NPC) is challenging owing to its rarity, complicated regional anatomy, and the intensity of therapy. In contrast to other head and neck cancers, the effect of facility volume has not been well described for NPC. The National Cancer Database was queried for patients with stage II-IVB NPC diagnosed from 2004 to 2014 and treated with definitive radiation. Patients with incomplete staging, unknown receipt or timing of treatment, unknown follow-up duration, incomplete socioeconomic information, or treatment outside the reporting facility were excluded. High-volume facilities (HVFs) were defined as the top 5% of facilities according to the annual facility volume. The present analysis included 3941 NPC patients treated at 804 facilities with a median follow-up duration of 59.4 months, including 1025 patients (26.0%) treated at HVFs. Treatment at HVFs was associated with significantly improved overall survival (OS) on multivariable analysis (hazard ratio 0.79, 95% confidence interval 0.69-0.90; P=.001). In propensity score-matched cohorts, 5-year OS was 69.1% versus 63.3% at HVFs versus lower volume facilities (LVFs), respectively (P=.003). Similar results were seen when facility volume...Continue Reading

Citations

Oct 30, 2019·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Mark P SittigZachary S Zumsteg
Jul 1, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jordan I TeitelbaumRalph Abi Hachem
Jun 1, 2019·The British Journal of Radiology·Elaine Johanna Limkin, Pierre Blanchard
Jan 7, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu-Pei ChenJun Ma
Jul 30, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tzu-Yu LaiChia-Jen Liu
Aug 24, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P BlanchardG Truc
Dec 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P BossiUNKNOWN EURACAN
Nov 13, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dan RenYongli Wang

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