PMID: 236989May 1, 1975

Factitious changes in binding of oxygen to hemoglobin when based on extracellular pH in the presence of certain blood additives like radiographic contrast media

Investigative Radiology
M A LichtmanM S Murphy


Construction of oxygen-hemoglobin DISSOCIATION CURVES BASED ON EXTRACELLULAR PH and using blood tonometered with 5 per cent CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic molecules like sucrose of poorly penetrating anionic aompounds like radiographic contrast materials. False conclusions regarding the position of the oxygen-hemoglobin dissociation curve can result because of the disturbance of the normal pH gradient between plasma and red cell induced by such chemicals.


Jan 1, 1976·British Journal of Haematology·M A LichtmanM Pogal
Jan 1, 1978·Acta Radiologica: Diagnosis·S BerglundB W Johansson
Jan 1, 1979·Acta Medica Scandinavica·K BerntorpB W Johansson

Related Concepts

Radiographic contrast media
Plasma Protein Binding Capacity
Hemoglobin Measurement
In Blood

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