Factor analysis of neuroanatomical and clinical characteristics of holoprosencephaly

Brain & Development
Jin S HahnN J Clegg

Abstract

The objective of this study is to better understand the relationship between neuroradiologic and clinical characteristics in holoprosencephaly (HPE) using the multivariate analysis called factor analysis. HPE is a brain malformation characterized by incomplete cleavage of the cerebral hemispheres and deep gray structures. We performed evaluations on 89 children with HPE that included their history, developmental assessment, and physical examination. Ten clinical variables included in factor analysis were the grade of spasticity, dystonia, choreoathetosis, hypotonia, mobility, upper extremity/hand function, expressive language, feeding/swallowing difficulty, endocrinopathies, and temperature dysregulation. Five neuroimaging variables graded by pediatric neuroradiologists were the grade of HPE (from least to most severe: lobar, semilobar, and alobar) and the degree of non-separation of caudate, lentiform, thalamic, and hypothalamic nuclei. Factor analysis using principle component extraction and varimax rotation was utilized. Four significant factors were identified: (1) neuroimaging/developmental factor, (2) motor factor, (3) hypothalamic/oromotor factor, and (4) hypotonia factor. These four factors accounted for 65.2% of the va...Continue Reading

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Citations

May 1, 2010·Pediatric Radiology·Nadine J Girard
Jul 4, 2007·Topics in Magnetic Resonance Imaging : TMRI·Diana P Rodriguez, Tina Young Poussaint
Jan 16, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chandrasekaran KaliaperumalDarach Crimmins
Sep 11, 2007·Brain & Development·Antonio Richieri-Costa, Lucilene Arilho Ribeiro
Jan 28, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Benjamin D SolomonMaximilian Muenke
Dec 14, 2011·Orvosi hetilap·Csaba DemendiZoltán Langmár
Nov 7, 2019·Current Opinion in Obstetrics & Gynecology·Paola QuaresimaElena Greco
Aug 18, 2017·The Journal of Obstetrics and Gynaecology Research·Mamoru MorikawaHisanori Minakami

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