PMID: 9166342May 1, 1997Paper

Factor V deficiency and menstruation: a gynecologic challenge

Obstetrics and Gynecology
K BennettC Pike

Abstract

Menorrhagia is a well-known complication of factor V deficiency. A 13-year-old girl with factor V deficiency presented with acute hemorrhage on day 4 of menses. Laboratory assessment revealed a hemoglobin of 36 g/L. The ultrasound appearance of a large loculated cystic mass was consistent with substantial intraperitoneal bleeding. Stabilization with blood products was followed by GnRH agonist therapy. Medical management was instituted effectively. Continued compliance with medication is essential to prevent recurrences. Factor V deficiency is rare. Coagulation disorders of this nature pose a challenge to gynecologists involved in patient management at the time of menses.

References

Aug 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A InbalU Martinowitz

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Citations

Nov 5, 1999·Journal of Pediatric and Adolescent Gynecology·M H Ellis, Y Beyth
Nov 17, 2007·Current Opinion in Obstetrics & Gynecology·Ihab El-HemaidiHassan Shehata
Sep 23, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·M VijapurkarK Ghosh
Sep 27, 2014·Journal of Pediatric and Adolescent Gynecology·M Stalnaker, P Esquivel
Jun 27, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Z Kaya

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