Factor V inhibitor after injection of human thrombin (tissucol) into a bleeding peptic ulcer

Endoscopy
J CaersH Reynaert

Abstract

Endoscopic injection of fibrin glue into a bleeding peptic ulcer is an effective and safe treatment modality. The present report describes a patient who developed rectal bleeding from an arteriovenous malformation after endoscopic injection of fibrin glue containing human thrombin into a gastric ulcer. Additional laboratory investigations revealed the presence of an inhibitor against coagulation factor V, which resulted in severe coagulopathy, triggering the bleeding. Acquired factor V inhibitors have frequently been reported with the use of bovine thrombin, but to our knowledge, they have never been documented in patients exposed to human thrombin. Endoscopists should be aware of this rare, but potentially serious, complication.

Citations

Nov 28, 2007·Annals of Hematology·Francisco Yuri Bulcão MacedoJohn Byrnes
Jan 8, 2010·Annals of Hematology·Andreas TiedeArnold Ganser
Jan 16, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Senta KurschelShizuo Oi
Aug 28, 2004·Gastrointestinal Endoscopy·Bret PetersenUNKNOWN Technology Assessment Committee, American Society for Gastrointestinal Endoscopy
Aug 13, 2005·The Journal of Trauma·Stephen W RothwellEvelyn Sawyer
Mar 20, 2008·Patient Safety in Surgery·Matthew W ReynoldsSrinath Samudrala
May 26, 2009·Patient Safety in Surgery·Paul NessUNKNOWN Recognition, Evaluation and Treatment of Acquired Coagulopathy Consensus (RETACC) Panel
Jun 14, 2008·Current Medical Research and Opinion·John ClarkMatthew W Reynolds
Jul 23, 2013·Gastrointestinal Endoscopy·Yasser M BhatSarah A Rodriguez
Aug 14, 2010·Biologicals : Journal of the International Association of Biological Standardization·Stephen W RothwellEvelyn Sawyer
May 19, 2009·Clinical Therapeutics·Frederick A OfosuMatthew W Reynolds
Aug 14, 2015·Journal of Thrombosis and Haemostasis : JTH·K Donohoe, R Levine
Oct 24, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·He ZhuJawed Fareed
Sep 27, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Viroj Wiwanitkit
Jan 20, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiMassimo Franchini
Sep 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Barbara LeusRonald Malfait
Dec 23, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Emmanuel J FavaloroMark Dean
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Zixian BaoMo Xian

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