Factor v Leiden homozygous genotype and pregnancy outcomes

Obstetrics and Gynecology
Christine Biron-AndréaniPROCARE-GEHT Group

Abstract

To assess the rate of early (first trimester) and late (second and third trimester) fetal loss in women who are factor V Leiden homozygous. Between December 1995 and February 2007, consecutive, unrelated white women who were factor V Leiden homozygous and who had been pregnant at least once were recruited from 10 French hemostasis units. For reasons of comparison, we included women who were factor V Leiden heterozygous and a group of noncarriers. The frequency of early and late fetal loss was assessed retrospectively and compared among the three groups. The effect of concomitant thrombophilic abnormalities was evaluated. The overall pregnancy outcome was reported. We analyzed 240 thromboprophylaxis-free pregnancies in 95 women who were factor V Leiden homozygous, 425 in 195 women who were factor V Leiden heterozygous, and 182 in 73 women who were noncarriers. The risk of late fetal loss was higher in women who were homozygous (13/95, 13.7%) compared with those who were noncarriers (1/73, 1.4%, odds ratio 11.41, 95% confidence interval 1.46-89.46, P=.002), whereas it was similar in women who were heterozygous and in noncarriers (6/195, 3.1% compared with 1/73, 1.4%, P=.68). The percentage of women with early fetal loss was simil...Continue Reading

References

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Citations

Dec 1, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jody Lynn Kujovich
Jul 28, 2010·Clinical Obstetrics and Gynecology·Robert M Silver, Cara C Heuser
Jul 2, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jelena VelickovicOliver Stojkovic
Nov 20, 2016·Human Fertility : Journal of the British Fertility Society·Jelena DjurovicGorana Stamenkovic

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