Factor V Leiden mutation and type 1 diabetes mellitus

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Asli Nar DemirerTomris Erbas

Abstract

Diabetes mellitus is considered to cause a tendency for arterial thrombosis. Recent studies addressed the association between venous and arterial disease. Resistance to activated protein C is one of the most common causes of venous thrombosis and linked to a single point mutation in the factor V gene, designated as factor V Leiden mutation. There is little information regarding the status of factor V Leiden mutation in type 1 diabetes. The aim of this study is to evaluate association among activated protein C sensitivity ratio, factor V Leiden mutation, and type 1 diabetes taking into account metabolic control, lipids and diabetic complications. The study population consisted of 47 healthy subjects (27.9 +/- 1.2 years) and 48 type 1 diabetic patients (27.9 +/- 1.1 years). Activated protein C sensitivity ratio was measured by activated partial thromboplastin time based assay. The presence of factor V Leiden mutation was determined by amplifying the fragments encompassing gene mutation by PCR. Mean normalized activated protein C sensitivity ratio values and prevalence of heterozygous factor V Leiden mutation were not significantly different between groups (1.08 +/- 0.03 and 6.3% in healthy subjects; 1.01 +/- 0.03 and 6.4% in type...Continue Reading

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Citations

Jun 30, 2009·Journal of Translational Medicine·Corrado LodigianiLidia Luciana Rota
Apr 8, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zohreh RahimiAbbas Parsian
Jul 6, 2016·Journal of Pediatric Hematology/oncology·Kazim KüçüktaşçiEnder Semiz

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