Factor V Leiden mutation, deficiency of antithrombin III and elevation of factor VIII in a child with ischemic stroke: a case report

Brain & Development
Ridvan DuranBetül Acunaş

Abstract

A 4-year-old boy was admitted with left hemiplegia. Thrombophilia marker examination resulted with factor V Leiden mutation heterozygosity, a deficiency of antithrombin III and a high level of factor VIII. Cranial computed tomography scan revealed an ischemic infarct in the region of right anterior cerebral artery. In the literature, combinations of multiple thrombophilia risk factors that trigger cerebral ischemic stroke in children have been emphasized. To our knowledge, this is the first child with these combinations of thrombophilia risk factors and ischemic stroke to be reported in the literature.

References

Dec 29, 1998·Archives of Neurology·G deVeberM Andrew
Sep 25, 2002·Journal of Child Neurology·Gülhis DedaNejat Akar
Apr 24, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·A Emin KurekciNejat Akar
Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ridvan DuranSerap Karasalihoğlu

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Citations

Dec 3, 2014·Jornal de pediatria·Vinicius M Torres, Vera A Saddi
Sep 14, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·H KunimotoS Okamoto
Aug 21, 2014·BMJ Case Reports·Sjoerd Adrianus Antonius Van den BergCoen Van Guldener

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