Factor V Leiden prevalence in venous thromboembolism patients

Chest
Christophe LeroyerDominique Mottier

Abstract

Recent findings have demonstrated a high frequency of activated protein C resistance in patients suffering from deep venous thrombosis (DVT). This abnormality has been related to a mutation in the factor V gene (at nucleotide position 1,691, guanine to adenine [G-->A] substitution). To assess the frequency of the mutation in unselected inpatients with a proved DVT. To study the clinical characteristics of such patients. All consecutive patients admitted to the hospital because of a clinical suspicion of DVT were eligible. Diagnosis of DVT with the help of venous ultrasound imaging or venography. Ventilation and perfusion lung scan was performed in all patients, and interpreted according to the Prospective Investigation of Pulmonary Embolism Diagnosis criteria; in patients with a low- or intermediate-probability lung scan, pulmonary angiography was requested. Polymerase chain reaction amplification was performed in patients with a proved DVT. A control group consisted of bone marrow volunteer donors. From July 1994 to November 1995, 165 patients were included. Thrombosis was considered as distal in 77 and proximal in 88; an associated pulmonary embolism (PE) was found in 75 patients. Of 165 patients, 24 (14.5%) showed the factor...Continue Reading

Citations

Apr 25, 2000·Annual Review of Medicine·C KearonJ Hirsh
Jun 2, 2010·Haematologica·Javier CorralVicente Vicente
Aug 26, 2010·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Mehrez M JadaonHend L Lewis
Aug 15, 1998·The American Journal of the Medical Sciences·W C Hooper, B L Evatt
Feb 19, 2008·Thrombosis Research·Soledad NoboaUNKNOWN EDITH Collaborative Study Group
Oct 9, 2007·The American Journal of Emergency Medicine·Michael W Dailey, Michelle P Tomassi
Jan 5, 2002·Emergency Medicine Clinics of North America·V Kim, J Spandorfer
Jul 1, 1999·Clinics in Chest Medicine·B M LegereA C Arroliga
Oct 21, 2000·Lancet·P Girard
Nov 28, 2006·Thrombosis Research·Emmanuel OgerUNKNOWN EDITH (Etude des Déterminants/Interaction de la THrombose veineuse) Collaborative Study Group
Aug 26, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·S MoussaouiN Abadi
Dec 2, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Charles J GlueckPing Wang
Feb 16, 2021·Thrombosis Research·Beate LuxembourgBettina Kemkes-Matthes
Aug 29, 2001·The American Journal of the Medical Sciences·R Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Elif KupeliFusun Oner Eyuboglu
Mediterranean Journal of Hematology and Infectious Diseases
Hanaa El-Karaksy, Mona El-Raziky
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Amir-Houshang ShemiraniZoltán Csiki
© 2021 Meta ULC. All rights reserved