PMID: 9438374Jan 23, 1998Paper

Factor V

The International Journal of Biochemistry & Cell Biology
J Rosing, G Tans

Abstract

Factor V is a single chain glycoprotein that plays an essential role in the regulation of blood coagulation. After initiation of coagulation, factor V is converted into factor Va through limited proteolysis. Factor Va acts as protein cofactor in the prothrombin-activating complex, which is comprised of the serine protease factor Xa, Ca2+ ions and a procoagulant membrane surface. Factor Va accelerates factor Xa-catalysed conversion of prothrombin into thrombin more than 10(4)-fold. The cofactor activity of factor Va in prothrombin activation is down-regulated by activated protein C (APC). The physiological importance of this regulatory pathway is demonstrated by the occurrence of hereditary thrombophilia in individuals with a genetic defect that makes factor Va less sensitive to proteolytic inactivation by APC (APC resistance).

References

Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R J JennyK G Mann
Sep 1, 1995·Current Opinion in Hematology·B Zöller, B Dahlbäck

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Citations

Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·E AjznerL Muszbek
Oct 19, 2012·Clinical Science·Victoria R RichardsonAngela M Carter
Mar 9, 2021·Blood·Eliza A RubenEnrico Di Cera

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