PMID: 1002840Nov 1, 1976Paper

Factor VII as a marker of hepatocellular synthetic function in liver disease

Journal of Clinical Pathology
G GreenI W Dymock


Factor VII levels have been measured in 100 patients with liver disease following parenteral vitamin K1 therapy. There was good agreement between specific factor VII measurements and the one-stage prothrombin time apart from six patients with compensated cirrhosis in whom the prothrombin time was prolonged despite the presence of normal factor VII levels. A mean activity of 58% was found in patients with cirrhosis. Cirrhotic patients with features of hepatic decompensation had a significantly lower mean level of activity (40%) than the "contrast" patients with surgical obstruction of the major bile ducts (93%). Patients with chronic active liver disease had moderate depression of factor VII levels and those with non-cirrhotic liver damage had mean activities similar to the contrast group. Factor VII levels could not be correlated with BSP retention but there was a correlation with serum albumin concentration. It is concluded that the prothrombin time using Quick test with a standardized thromboplastin showing good sensitivity to factor VII, eg, the Manchester reagent (BCT), provides a reliable index of coagulability in chronic liver disease, and specific factor VII assays are not indicated.


Mar 1, 1975·British Journal of Haematology·I W DymockJ M Thomson
Mar 1, 1970·American Journal of Clinical Pathology·S ZuckerE C Hall
Mar 1, 1969·Journal of Clinical Pathology·G W DonaldsonJ Richmond


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Related Concepts

Factor VII
Fibrosis, Liver
Liver Dysfunction
Liver Function Tests

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