PMID: 1002840Nov 1, 1976Paper

Factor VII as a marker of hepatocellular synthetic function in liver disease

Journal of Clinical Pathology
G GreenI W Dymock

Abstract

Factor VII levels have been measured in 100 patients with liver disease following parenteral vitamin K1 therapy. There was good agreement between specific factor VII measurements and the one-stage prothrombin time apart from six patients with compensated cirrhosis in whom the prothrombin time was prolonged despite the presence of normal factor VII levels. A mean activity of 58% was found in patients with cirrhosis. Cirrhotic patients with features of hepatic decompensation had a significantly lower mean level of activity (40%) than the "contrast" patients with surgical obstruction of the major bile ducts (93%). Patients with chronic active liver disease had moderate depression of factor VII levels and those with non-cirrhotic liver damage had mean activities similar to the contrast group. Factor VII levels could not be correlated with BSP retention but there was a correlation with serum albumin concentration. It is concluded that the prothrombin time using Quick test with a standardized thromboplastin showing good sensitivity to factor VII, eg, the Manchester reagent (BCT), provides a reliable index of coagulability in chronic liver disease, and specific factor VII assays are not indicated.

References

Mar 1, 1975·British Journal of Haematology·I W DymockJ M Thomson
Mar 1, 1970·American Journal of Clinical Pathology·S ZuckerE C Hall
Mar 1, 1969·Journal of Clinical Pathology·G W DonaldsonJ Richmond

Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B CornillonR Eloy
May 23, 2001·Thrombosis Research·M Koldas, F Uras
Nov 28, 1981·Lancet·C R Madeley, J McQuillin
Nov 28, 1981·Lancet·H C Dominick, A H Sutor
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Sylvie LebelKatryn N Furuya
Sep 10, 2003·Journal of Pediatric Gastroenterology and Nutrition·Jeffrey B BrownEstella M Alonso
Mar 1, 1986·Gut·D A Kelly, E G Tuddenham
Feb 1, 1989·Mayo Clinic Proceedings·D M RitterR A Krom
Oct 22, 2015·British Journal of Haematology·Stefano BarcoSaskia Middeldorp
Dec 6, 2007·Alimentary Pharmacology & Therapeutics·M Peck-Radosavljevic
May 12, 2007·Pediatric Transplantation·Udeme Ekong
Jul 5, 2005·Critical Care Clinics·Jody L Kujovich
May 12, 2017·Thrombosis and Haemostasis·Surapong LertthammakiatAmpaiwan Chuansumrit
Aug 22, 2006·Paediatric Anaesthesia·Jesus De SantiagoAntonio Pérez-Gallardo
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May 22, 2017·EFSA Journal·EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)Monika Neuhäuser-Berthold
Nov 1, 1990·Scandinavian Journal of Gastroenterology·N NishimuraK Ozawa

Related Concepts

Cholestasis
Factor VII
Fibrosis, Liver
Liver Dysfunction
Liver Function Tests
Phyllohydroquinone
Thrombotest

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