PMID: 11898395Mar 20, 2002Paper

Factor VIIa/tissue factor-induced signaling: a link between clotting and disease

Vitamins and Hormones
Usha R Pendurthi, L Vijaya Mohan Rao

Abstract

Tissue factor is a cellular receptor for plasma clotting factor VII. In health, tissue factor is constitutively expressed in many cells, such as fibroblasts and keratinocytes, but is absent in vascular cells that come in contact with blood. However, tissue factor is induced in vascular cells in certain pathophysiological conditions. Thus, vessel wall injury or a disease condition allows blood to come in contact with tissue factor, resulting in factor VII binding to tissue factor. Once native factor VII complexed with tissue factor is converted to the enzyme factor VIIa, the complex triggers the clotting cascade that ultimately leads to fibrin formation. In addition to its established role in coagulation, molecular links between factor VIIa/tissue factor and various biological processes, such as development, inflammation, and tumor metastasis, are also evident. Recent studies suggest that factor VIIa/tissue factor affects various cellular processes by inducing intracellular signaling. Emerging evidence suggest that factor VIIa/tissue factor participates in cell signaling by two distinct mechanisms: proteolysis-independent signaling via the cytoplasmic domain of tissue factor, and proteolysis-dependent signaling, which is indepen...Continue Reading

Citations

Mar 31, 2007·Journal of Thrombosis and Thrombolysis·Massimo FranchiniGiuseppe Lippi
Jul 25, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M MonroeU Hedner
Oct 6, 2012·The Journal of Biological Chemistry·Beatriz Sánchez-SolanaRakesh Kumar
Dec 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·L Vijaya Mohan Rao, Usha R Pendurthi
May 10, 2003·Blood·Brit B SorensenLars C Petersen
Sep 30, 2006·Journal of Thrombosis and Thrombolysis·Alessandro VolpeGian Cesare Guidi
Jul 30, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M Lopes-Bezerra, S G Filler
Aug 2, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Lindsay M Pozza, Richard C Austin
Sep 17, 2004·Journal of Toxicology and Environmental Health. Part a·Alexei Iakhiaev, Steven Idell

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