Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series.

A&A Practice
Ali TabatabaiMichael Mazzeffi

Abstract

Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.

References

Jun 7, 1990·The New England Journal of Medicine·T van der PollJ W ten Cate
Oct 3, 2006·British Journal of Haematology·Peter W CollinsGeorge P Findlay
Aug 17, 2019·Critical Care : the Official Journal of the Critical Care Forum·Takashi ItoToshiaki Iba
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Mar 17, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Huan HanCheng-Liang Zhu
Mar 27, 2020·Emerging Microbes & Infections·Taisheng LiWenhong Zhang
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 9, 2020·The New England Journal of Medicine·Yan ZhangShuyang Zhang

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Citations

Aug 25, 2020·Thrombosis and Haemostasis·Upendra K KatneniChava Kimchi-Sarfaty
Aug 28, 2020·Reviews in Medical Virology·Benjamin Gallo MarinIan C Michelow
Nov 13, 2020·International Journal of Laboratory Hematology·Robert BellJohn L Frater
Mar 31, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Prakash A PatelMichael A Mazzeffi
May 16, 2021·Annals of the Academy of Medicine, Singapore·Saikat MitraKollengode Ramanathan
Jun 22, 2021·Frontiers in Immunology·Xiang-Zhi FangYou Shang
Jul 22, 2021·International Journal of Laboratory Hematology·Katrien M J Devreese

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