PMID: 6411773Sep 1, 1983Paper

Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid

Journal of Clinical Pathology
H R HarachE D Williams

Abstract

Factor VIII-related antigen is a recognised marker of endothelial cells. A brief immunocytochemical study of its distribution in follicular carcinoma of the thyroid and its value in the recognition of vascular invasion by this tumour has been carried out. Ten cases of follicular carcinoma of the thyroid were studied. In each strong endothelial staining was found in the majority of vessels in the adjacent normal thyroid. Lymphatic endothelium was negative. In eight of the 10 cases the staining of vessels within the tumour was absent or very weak. Staining was also absent in the majority of vessels completely occluded by tumour, but was present in the endothelium of vessels only partly occluded by tumour. It is concluded that factor VIII-related antigen staining has only limited value in the recognition of vascular invasion in follicular carcinoma. The absence of vascular staining in the tumour leads us to suggest that inhibition of factor VIII production by the tumour could be a possible mechanism which facilitates vascular invasion and metastasis.

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Citations

Feb 1, 1990·Cancer Metastasis Reviews·P N Belloni, R J Tressler
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·B M Hultberg, H Svanholm
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·G HerrmannK Hübner
Sep 1, 1990·The Japanese Journal of Surgery·K InadaY Ozeki
Jul 13, 2002·Endocrine Pathology·Maria L. Carcangiu
Dec 1, 1991·Trends in Pharmacological Sciences·S A McCarthyR Bicknell
Oct 4, 2012·Clinical and Experimental Pharmacology & Physiology·Hui-Yu YangZhi-Ming Yang
Mar 9, 2010·Diagnostic Pathology·Xiaoqi LinJan F Silverman
Nov 26, 2013·International Journal of Pharmaceutics·Hao HuKaichun Wu
Nov 1, 1993·In Vitro Cellular & Developmental Biology. Animal·P W Hewett, J C Murray
Apr 1, 1993·In Vitro Cellular & Developmental Biology. Animal·P W HewettM Woodcock
Jan 1, 1985·Ultrastructural Pathology·M A Sobrinho-SimõesJ V Johannessen
Sep 24, 2013·Human Pathology·Liping LiuSamuel M Cohen
Mar 8, 2011·Archives of Medical Research·Yun-fei BianChuan-shi Xiao
Oct 12, 2001·Microscopy Research and Technique·J P SleemanP Baumann
Feb 14, 2002·Anatomia, histologia, embryologia·H UlgerM K Pratten
Jun 1, 1990·Endocrine Pathology·Virginia A LiVoisi
Jun 15, 2006·World Journal of Gastroenterology : WJG·Eugenio GaudioPaolo Onori
Jun 26, 2001·Pathology International·N AidaS Tanaka
Sep 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·J ChemnitzI Lorenzen
Sep 10, 2020·Clinical Implant Dentistry and Related Research·Pravej SerichetaphongseAtiphan Pimkhaokham

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