Factor VIII inhibitor in insulin-dependent diabetes mellitus

American Journal of Hematology
T Wajima, G Hall

Abstract

Acquired factor VIII inhibitor was found in a 69-year-old white male with insulin-dependent diabetes mellitus. He presented with left lower abdominal pain and hematoma after a fall. Preoperative hemostasis studies were normal except for prolonged aPTT. Prolonged aPTT was not corrected by 1:1 mixture with normal fresh plasma and incubation showed further prolongation with time. Factor VIII:c was 3.5%. The inhibitor titer was 7.5 Bethesda units. The possible mechanism causing antibody to factor VIII was postulated to be an autoimmune process and/or increased immunogenicity owing to glycosylation of factor VIII coagulant protein.

References

Jan 1, 1974·Haemostasis·K Lechner
Oct 1, 1984·Annals of Internal Medicine·M BrownleeA Cerami

❮ Previous
Next ❯

Citations

Dec 1, 1993·Annals of Hematology·J MateoJ Fontcuberta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.