PMID: 1206122Dec 1, 1975Paper

Factor VIII levels during the course of acute hepatitis in a haemophiliac

Journal of Clinical Pathology
B G GazzardR Williams

Abstract

A 51-year-old patient with haemophilia since childhood (usual factor VIII level 14%) developed acute viral hepatitis type B two months after an operation which had been covered by cryoprecipitate. The course of the hepatitis following admission was severe with encephalopathy and ascites. Evidence of intravascular coagulation with an increased radioactive fibrinogen turnover was also present. The factor VIII level measured by a one-stage clotting factor assay rose rapidly to 200% of normal and remained at this level for two weeks, and factor-VIII-related antigen as measured by electroimmunoassay also became greatly elevated (900% of normal). The possible mechanisms underlying those surprising changes are discussed.

References

Mar 14, 1970·Lancet·M O RakeR Williams
Sep 1, 1971·Journal of Clinical Pathology·M J O'SheaG M Pannell
Dec 1, 1971·Annals of Internal Medicine·V Gurewich, E Hutchinson
Apr 1, 1969·British Journal of Haematology·J Niemetz, H L Nossel
Sep 1, 1970·Vox Sanguinis·J H Lewis
Jul 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·C MerskeyA J Johnson
Oct 1, 1952·Archives of Biochemistry and Biophysics·T ASTRUP, S MULLERTZ
Jul 1, 1961·Journal of Clinical Pathology·G I INGRAM

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Citations

Nov 1, 1984·European Journal of Pediatrics·K HeyneJ Schaub

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