Factor VIII structure and function

Blood Reviews
P A Foster, T S Zimmerman

Abstract

The relatively recent ability to obtain highly purified factor VIII (FVIII) preparations from plasma products, the cloning of the FVIII gene, and the expression of recombinant FVIII have provided the basis for significant advancements in the understanding of the structure-function relationships of FVIII. Evaluation of the molecular structure of FVIII has revealed the presence of domains of significant internal amino acid sequence homology as well as homology with similar structural domains of factor V. Specific proteolytic cleavage sites have been identified in the molecule and the use of site directed mutagenesis has identified those proteolytic cleavage sites required for the activation of FVIII. Deletion and substitution variants of FVIII as well as the precise epitope mapping of FVIII antibodies which inhibit the procoagulant function of the protein or its binding to von Willebrand factor have provided insight into the identification of regions of FVIII which are required for normal function.

References

Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C A FulcherT S Zimmerman
Jan 1, 1987·Archives of Biochemistry and Biophysics·F J WalkerP J Fay
Jan 1, 1988·Annual Review of Biochemistry·K G MannS Krishnaswamy
Jun 23, 1986·Biochimica Et Biophysica Acta·P J FayV J Marder
Nov 1, 1986·British Journal of Haematology·M E SoberanoM B Zucker
Jul 1, 1987·European Journal of Biochemistry·R J HamerJ J Sixma
Sep 1, 1987·European Journal of Biochemistry·R J HamerJ J Sixma
Jan 29, 1988·Biochimica Et Biophysica Acta·P J Fay
Apr 1, 1969·Annals of Internal Medicine·F Rosner
Sep 9, 1967·Nature·H C Hemker, M J Kahn
Sep 1, 1983·British Journal of Haematology·A YoshiokaA L Bloom
Nov 22, 1984·Nature·J GitschierR M Lawn
Nov 22, 1984·Nature·G A VeharD J Capon
Nov 30, 1984·Biochemical and Biophysical Research Communications·R M BertinaA van Wijngaarden
Nov 18, 1981·Biochimica Et Biophysica Acta·A LajmanovichG Marguerie
Oct 15, 1981·The Biochemical Journal·L O Andersson, J E Brown
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C A Fulcher, T S Zimmerman
Apr 1, 1982·The Journal of Clinical Investigation·M B Hultin
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P J FayV J Marder
Jan 1, 1980·Annual Review of Biochemistry·C M Jackson, Y Nemerson
Sep 1, 1936·The Journal of Clinical Investigation·A J Patek, R P Stetson

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Citations

Dec 9, 2003·Journal of Biosciences·G M Bhopale, R K Nanda
May 1, 1996·Annals of Hematology·J BatlleM F López-Fernández
Jan 6, 1994·The New England Journal of Medicine·L W Hoyer
Nov 1, 1995·Australian Veterinary Journal·T StokolP D Mansell
Jan 1, 1995·Veterinary Clinical Pathology·T. StokolP. D. Mansell
Apr 30, 1998·Journal of Veterinary Internal Medicine·T Stokol, B Parry
Feb 12, 2002·Molecular Pathology : MP·D J Bowen
Apr 16, 2002·Molecular Pathology : MP·D J Bowen
Oct 1, 1994·The Journal of Clinical Investigation·J G Gilles, J M Saint-Remy
Jun 27, 2006·The AAPS Journal·Vivek S Purohit, Sathyamangalam V Balasubramanian
Dec 3, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Puneet GaitondeSathy V Balu-Iyer
Jul 30, 2005·Journal of Pharmaceutical Sciences·Karthik RamaniSathyamangalam V Balasubramanian
Apr 29, 2005·Journal of Pharmaceutical Sciences·Karthik RamaniSathyamangalam V Balasubramanian
Dec 24, 2005·Journal of Pharmaceutical Sciences·Vivek S PurohitSathyamangalam V Balasubramanian
Jul 1, 1991·Transfusion Medicine Reviews·D Lillicrap
Feb 13, 2013·Journal of Thrombosis and Haemostasis : JTH·K M Valentijn, J Eikenboom
Apr 1, 1990·Baillière's Clinical Haematology·P Meulien, E G Tuddenham
Oct 1, 1989·Baillière's Clinical Haematology·E G Tuddenham
Oct 15, 1991·Biochemical and Biophysical Research Communications·P R GanzF Luison
Nov 26, 2003·Biochimica Et Biophysica Acta·Vivek S PurohitSathyamangalam V Balasubramanian
Jan 23, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Cláudio Roberto S MattosoJosé Eduardo Corrente
Jan 12, 2011·Journal of Biotechnology·Mille Petersen KolindLaust Bruun Johnsen

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